Texas Research for Lissencephaly and Brain Malformations

2012 research involves the study of cortical malformations produced by disturbances in the Lis1, Reeler, and Doublecortin genes. Because these brain malformations are characterized as neuronal migration disorders, Dr. Clark and his colleagues are investigating how these genes and their respective signaling pathways participate in neuronal movement and cortical lamination.

For more information see the website http://nri.texaschildrens.org/families-and-patients/treatment-programs-texas-childrens-hospital

Dr. Gary D. Clark became chief of Pediatric Neurology and Developmental Neuroscience in 2004. Dr. Clark also leads the Clark Laboratory at The Gordon and Mary Cain Foundation Pediatric Neurology Research Foundation Laboratories at Texas Children’s Hospital. During his tenure, Dr. Clark has recruited several highly qualified faculty members and fellows to further develop a growing and dynamic child neurology program. Under his direction, the section is actively involved in translating new scientific discoveries into effective bedside treatments, and is strongly committed to addressing the significant challenges present in today’s changing healthcare environment.

The Clark Laboratory focuses on revealing the cellular and molecular mechanisms underlying human brain development. Current research involves the study of cortical malformations produced by disturbances in the Lis1, Reeler, and Doublecortin genes. Because these brain malformations are characterized as neuronal migration disorders, Dr. Clark and his colleagues are investigating how these genes and their respective signaling pathways participate in neuronal movement and cortical lamination.

Dr. Clark was the recipient of the 2004 Sidney Carter Award from the American Academy of Neurology (AAN), the highest honor awarded by the AAN, in recognition of his outstanding work in the field of child neurology/developmental neurobiology. Dr. Clark, an associate professor of pediatrics at Baylor College of Medicine, also leads the pediatric neurology section of the Department of Pediatrics.

Dr. Clark earned his M.D. at Louisiana State University Medical College in New Orleans. He is board certified in neurology with a special qualification in child neurology. He is a member of the Society for Pediatric Research, the American Academy of Pediatrics, and the American Academy of Neurology. He sits on the research committee of the Child Neurology Society and the Investigation Workshop Committee of the American Epilepsy Society.